Akademik Veri Yönetim Sistemi
POLISH JOURNAL OF VETERINARY SCIENCES, cilt.26, sa.3, ss.343-347, 2023 (SCI-Expanded, Scopus)
The aim of this study is to determine the protective efficacy of anise in cerebral ischemia and reperfusion injury in rats.In this study, 28 Wistar Albino rats, weighing 250-300 grams (g), were used. Four groups were formed with 7 rats in each group. Group 1 (n=7): Control group, Group 2 (n=7): Anise group, 5 mL/kg/day of anise aqueous extract prepared according to Gamberini's protocol was given orally by gavage for 30 days. Group 3 (n=7): Cerebral ischemia reperfusion (CIR) group, at the beginning of the experiment, 30 minutes of cerebral ischemia and 1 hour of reperfusion were induced and the animals were sacrificed by exanguination. Group 4 (n=7): Anise+ CIR group, After administering 30 days of anise's aqueous extract, CIR was induced and the study was terminated.TOS values of the Anise+ CIR group was significantly lower than that of the CIR group (p<0.05). Il-6 and TNF-alpha values of the CIR group were significantly higher than the Anise+ CIR group (p<0,05).Our study revealed that anise ameliorates oxidative damage and inflammation due to cerebral ischemia/reperfusion, by reducing the levels of inflammatory cytokines (TNF-alpha, Il-6).