Akademik Veri Yönetim Sistemi
Sakarya Tıp Dergisi, cilt.10, sa.2, ss.277-284, 2020 (Hakemli Dergi)
Objective Oxidative stress is one of the essential factors in the development of Hypertension (HT). Hair whitening is a visual sign of oxidative stress. We hypothesized that theintensity of premature hair whitening might predict HT development, and we aimed to test it.Materialsand MethodsA total of 172 healthy males with different stages of hair whitening were included in the study and evaluated after an average of 86 months. During the follow-up, wecompared the data of patients diagnosed with HT to those who remained healthy.Results Fifty-five (32%) of 172 patients were diagnosed with HT during follow-up period. In terms of demographic characteristics, age (41.48 ± 6.39 vs 44.36 ± 5.25 years; p=0.013),waist circumference (97.52 ± 10.87 vs 104.80 ± 11.94 cm; p=0.004), and body-mass index (27.61 ± 3.56 vs 30.20 ± 3.55 kg/m2; p<0,001) were higher in the HT group,whereas smoking history (p=0.211) was similar between the groups. In univariate analysis carotid intima-media thickness (CIMT)(p=0.013), gamma-glutamyl transferase(GGT)(p=0.021), and uric acid (p<0.001) levels were higher in the HT group; on the contrary, estimated glomerular filtration rate (eGFR)(p=0.039) and high-densitylipoprotein (HDL) levels (p=0.026) were lower in this group. There was no difference between groups in terms of hair whitening stage and intensity. In multivariate analysisage (OR=0.143, 95%CI (1.002-1.328), p=0.046), eGFR (OR= -0.058, 95%CI (0.895-0.995), p=0.032), uric acid (OR=0.567, 95%CI (1.032-3.015), p=0.038), GGT (OR=0.030,95%CI (1.001-1.060), p=0.041), and HDL (OR=-0.129, 95%CI (0.783- 0.986), p=0.028) were independently associated with de nova HT. Body-mass index, CIMT, and theleukocyte count were similar between the groups.Conclusion Premature hair whitening is not predictive in determining the development of HT in young and middle-aged healthy men.