De novo postmenopausal endometriosis during tibolone treatment: A case report and review of the literature

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dilbaz B., Tekin Y., dilbaz S., haberal A.

Gynecological Surgery, vol.5, no.3, pp.235-237, 2008 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 5 Issue: 3
  • Publication Date: 2008
  • Doi Number: 10.1007/s10397-007-0355-9
  • Journal Name: Gynecological Surgery
  • Journal Indexes: Scopus
  • Page Numbers: pp.235-237
  • Recep Tayyip Erdoğan University Affiliated: No


Abstract Endometriosis is uncommon before puberty and
after menopause as it is an estrogen-dependent disease. A
case is presented of postmenopausal endometriosis encountered
in a patient who had received tibolone (Livial, Organon,
Cambridge, UK) 1 year before the diagnosis of the adnexal
mass for 3 months for relief from vasomotor symptoms and
had the medication stopped because of fibrocystic disease of
the breast. Transvaginal ultrasonography showed homogeneous
cystic adnexal mass of 36×26 mm with no internal
echoes in the right ovary. Laparoscopic right salpingooophorectomy
was performed and the histopathological examination
of the cyst showed an endometriotic cyst. Most of the cases
with postmenopausal endometriosis are associated with the
use of hormone replacement therapy (HRT). However,
tibolone is recommended in hormone replacement therapy
of postmenopausal symptomatic women who have a past
history of hormone-dependent tumors such as endometriosis.
There is restricted data in the literature about tibolone use and
recurrence or de novo formation of endometriosis.