Neutrophil-to-Lymphocyte Ratio Increases in Patients With Dry Eye


SEKERYAPAN B., Uzun F., BUYUKTARAKCI S., BULUT A., ONER V.

CORNEA, vol.35, no.7, pp.983-986, 2016 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 7
  • Publication Date: 2016
  • Doi Number: 10.1097/ico.0000000000000872
  • Journal Name: CORNEA
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.983-986
  • Keywords: dry eye disease, neutrophil-to-lymphocyte ratio, C-reactive protein, RETINAL VEIN OCCLUSION, OCULAR SURFACE, INFLAMMATORY CYTOKINES, DIABETIC-RETINOPATHY, RISK-FACTORS, DISEASE, PROGRESSION, PREVALENCE, PREDICTOR, SURVIVAL

Abstract

Purpose:To assess the neutrophil-to-lymphocyte ratio (NLR) as an indicator of inflammation in patients with non-Sjogren dry eye disease.Methods:Serum NLR and C-reactive protein values were determined in 33 patients with dry eye and in 32 controls. The NLR was calculated by dividing the neutrophil count by the lymphocyte count.Results:Characteristics of the dry eye and control groups were similar. The mean NLR value was 2.8 1.4 (range: 1.1-6.1) in the dry eye group and 1.6 +/- 0.7 (range: 0.8-2.8) in the control group (P = 0.002, t test). The mean C-reactive protein value was 0.6 +/- 0.7 mg/dL (range: 0-2.3 mg/dL) in the dry eye group and 0.5 +/- 0.6 mg/dL (range: 0-1.9 mg/dL) in the control group (P = 0.307, t test).Conclusions:The NLR values were found to be higher in patients with non-Sjogren dry eye than in controls. This result suggests that non-Sjogren dry eye disease may be associated with systemic inflammation or the NLR values may increase in local inflammatory ocular diseases.