Synthesis of 1,2,4-Triazole Derivatives and Determination of Protonation Constant


İSLAMOĞLU F. , Kahveci B., Bekircan O.

ASIAN JOURNAL OF CHEMISTRY, vol.21, no.7, pp.5523-5534, 2009 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 7
  • Publication Date: 2009
  • Title of Journal : ASIAN JOURNAL OF CHEMISTRY
  • Page Numbers: pp.5523-5534

Abstract

A microwave irradiation method has been developed for the synhesis of some 1,2,4-triazole derivatives using environmentally benign solvent ethanol in open vessels. Twelve 1,2,4-triazole derivatives were synthesized in good yields. The newly synthesized compounds (2a-f and 3a-f) were titrated potentiometrically with tetrabutylammonium hydroxide in isopropyl alcohol. t-butyl alcohol, acetonitrile and N,N-dimethyl formamide (DMF) and the half-neutralization potential values and the corresponding pKa values were determined.