Synthesis of 1,2,4-Triazole Derivatives and Determination of Protonation Constant

İSLAMOĞLU F., Kahveci B., Bekircan O.

ASIAN JOURNAL OF CHEMISTRY, cilt.21, sa.7, ss.5523-5534, 2009 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 7
  • Basım Tarihi: 2009
  • Dergi Adı: ASIAN JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.5523-5534
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

A microwave irradiation method has been developed for the synhesis of some 1,2,4-triazole derivatives using environmentally benign solvent ethanol in open vessels. Twelve 1,2,4-triazole derivatives were synthesized in good yields. The newly synthesized compounds (2a-f and 3a-f) were titrated potentiometrically with tetrabutylammonium hydroxide in isopropyl alcohol. t-butyl alcohol, acetonitrile and N,N-dimethyl formamide (DMF) and the half-neutralization potential values and the corresponding pKa values were determined.