TURKISH JOURNAL OF GASTROENTEROLOGY, vol.25, no.6, pp.639-643, 2014 (Peer-Reviewed Journal)
Article / Article
TURKISH JOURNAL OF GASTROENTEROLOGY
Science Citation Index Expanded, Scopus, TR DİZİN (ULAKBİM)
Crohn's disease, ulcerative colitis, cannabinoid receptor-2, polymorphism, CB2 RECEPTOR, ULCERATIVE-COLITIS, CROHNS-DISEASE, PATHOGENESIS, RISK, EPIDEMIOLOGY, POLYMORPHISM, GENETICS, COLON, MICE
Background/Aims: The endocannabinoid system can exert beneficial effects on gastrointestinal inflammation, and cannabinoid receptor-2 (CB2) agonists may represent a new therapeutic approach in inflammatory bowel disease (IBD). A functional CB2 Q63R polymorphism (rs35761398) in the CNR2 gene has been shown to affect the immunomodulating properties of the CB2 receptor. We sought to investigate whether the functional CB2 Q63R polymorphism (rs35761398) is associated with IBD susceptibility in a Turkish clinical sample.