Relationship Between Serum Endocan Levels and Other Predictors of Endothelial Dysfunction in Obese Women

MERCANTEPE F., Baydur Sahin S., Cumhur Cure M., Karadag Z.

ANGIOLOGY, cilt.74, sa.10, ss.948-957, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 74 Sayı: 10
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1177/00033197221129358
  • Dergi Adı: ANGIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EMBASE, Food Science & Technology Abstracts, MEDLINE
  • Sayfa Sayıları: ss.948-957
  • Anahtar Kelimeler: endocan, endothelial dysfunction, obesity, INTIMA-MEDIA THICKNESS, CELL-SPECIFIC MOLECULE-1, CIRCULATING ADHESION MOLECULES, CARDIOVASCULAR RISK, ADIPONECTIN, INFLAMMATION, POPULATION, VALUES, ATHEROSCLEROSIS, ASSOCIATION
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

Endocan, or endothelial cell-specific molecule-1 (ESM-1), is a potential inflammatory marker implicated in endothelial dysfunction. The purpose of this study was to determine the correlation between serum endocan levels and the presence and severity of endothelial dysfunction, and the relationships with serum intracellular adhesion molecule-1 (ICAM-1), adiponectin (a marker of inflammation), high sensitivity C-reactive protein (hsCRP) levels, and carotid intima-media thickness (cIMT) in obese subjects. Serum endocan, ICAM-1, adiponectin, hsCRP levels, and cIMT were evaluated in 76 obese women (BMI > 30 kg/m(2)) and 53 controls (BMI < 25 kg/m(2)). ICAM-1 (P = .01), hs-CRP (p < 0.001), and cIMT (p < .001) were significantly higher, while adiponectin (P = .006) was significantly lower, in obese women compared with the controls. Serum endocan levels were similar between the obese (470.5 +/- 171.3 pg/mL) and controls (471.9 +/- 146.3 pg/mL) (P = .732). There was no correlation between serum endocan values and the endothelial dysfunction markers, hsCRP (r = -.021), ICAM-1 (r = -.054), adiponectin (r = .113), or cIMT (r = -.060) in obesity. Endocan is not a suitable marker of endothelial dysfunction in the context of obesity. More research is required to evaluate the role of endocan in the regulation of inflammatory processes in obesity.