Evaluation of periodontal status of patients with rheumatoid arthritis: A retrospective study

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YEMENOĞLU H., BEDER M., CÜRE O., BOSTAN S. A.

Medicine Science, cilt.14, ss.162-168, 2025 (Hakemli Dergi)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14
  • Basım Tarihi: 2025
  • Doi Numarası: 10.5455/medscience.2024.12.177
  • Dergi Adı: Medicine Science
  • Derginin Tarandığı İndeksler: TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.162-168
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

Periodontal diseases may alter some systemic diseases and general health by changing the host response. In addition, some systemic diseases affect periodontal health.

This study purposed to assess the periodontal status of individuals with rheumatoid arthritis (RA) receiving different drug treatments. A total of 160 individuals,

80 with RA and 80 systemically healthy individuals, were retrospectively included in the study. Individuals with RA were classified into two groups based on the

medications they used, conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs)+glucocorticoids (n=40) and csDMARDs+TNF-α inhibitor

(n=40). The participants’ plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing depth (PD), and clinical attachment loss (CAL) values were

noted. In addition, duration of disease, type of medication, duration of medication use, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), Disease

Activity Score (DAS) 28-ESR, DAS 28-CRP, tender joint count (TJC), swollen joint count (SJC), rheumatoid factor, and visual analog scale (VAS) values were

recorded. Appropriate statistical tests were performed. Compared with individuals with RA, BOP, GI, PI, and PD values were higher in the systemically healthy

individuals (p<0.05). When compared according to the drug treatments used, PI, GI, and BOP values of the patients using csDMARDs+TNF-α inhibitor were

significantly lower and CAL was significantly higher than the systemically healthy individuals (p<0.05). Moreover, a positive correlation was found between

disease duration and PD and CAL values in the patients using csDMARDs+TNF-α inhibitor. The worse periodontal parameters in patients with RA using

csDMARDs+glucocorticoids compared with those using csDMARDs+TNF-α inhibitor may be due to differences in the mechanisms of action of the drugs. More

comprehensive studies are needed to determine the relationship between periodontal status and RA.