Protective effect of the vasopressin agonist terlipressin in a rat model of contrast-induced nephropathy.


Ari E., Yılmaz Y., Kedrah A. E. , Alahdab Y., Cakalagaoglu F., Arikan H., ...More

American journal of nephrology, vol.33, no.3, pp.269-76, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 3
  • Publication Date: 2011
  • Doi Number: 10.1159/000324764
  • Journal Name: American journal of nephrology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.269-76
  • Keywords: Contrast-induced nephropathy, Terlipressin, Acute renal failure, ENDOTHELIAL GROWTH-FACTOR, HEPATORENAL-SYNDROME, KIDNEY INJURY, THERAPY, METAANALYSIS, PREVENTION, STRATEGIES, CIRRHOSIS, TRIALS
  • Recep Tayyip Erdoğan University Affiliated: No

Abstract

Background/Aims: Contrast-induced nephropathy (CIN) remains a leading cause of iatrogenic acute renal failure. Terlipressin, a long-acting analog of vasopressin, may improve renal function. This study aimed to investigate the possible protective effect of terlipressin against the development of experimental CIN in rats. Methods: Wistar albino rats (n = 32) were allocated randomly into four equal groups of 8 each, i.e. control, terlipressin, contrast media (CM), and terlipressin plus contrast media (TCM). CIN was induced by intravenous administration of indomethacin (10 mg/kg), N-nitro L-arginine methyl ester (L-NAME, 10 mg/kg, twice at 15 and 30 min), and high-osmolar contrast media meglumine amidotrizoate 60%. Renal function parameters, kidney histology, and tubular expression of vascular endothelial growth factor (VEGF) were determined. Results: Mean serum creatinine levels were decreased (p < 0.05) and creatinine clearance (p < 0.05) increased in the TCM group compared with the group. Notably, rats in the TCM group displayed less tubular necrosis (p < 0.05), medullary congestion (p < 0.05), and a reduced tubular expression of VEGF (p < 0.05) compared with the CM group. Conclusion: These results demonstrate that terlipressin can inhibit the development of CIN. Copyright (C) 2011 S. Karger AG, Basel