A study on 4-acylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones

Alkan M., YUEKSEK H., Islamoglu F., Bahçeci S., CALAPOGLU M., ELMASTAS M., ...More

MOLECULES, vol.12, no.8, pp.1805-1816, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 8
  • Publication Date: 2007
  • Doi Number: 10.3390/12081805
  • Journal Name: MOLECULES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1805-1816
  • Recep Tayyip Erdoğan University Affiliated: Yes


Five novel 3-alkyl-4-phenylacetylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones (2) were synthesized by the reactions of 3-alkyl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5ones (1) with phenylacetyl chloride and characterized by elemental analyses and IR, (HNMR)-H-1, C-13-NMR and UV spectral data. The newly synthesized compounds 2 were titrated potentiometrically with tetrabutylammonium hydroxide in four non-aqueous solvents such as isopropyl alcohol, tert-butyl alcohol, acetonitrile and N,N-dimethylformamide, and the half-neutralization potential values and the corresponding pK(a) values were determined for all cases. In addition, these new compounds and five recently reported 3-alkyl-4-(p-methoxybenzoylamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones (3) were screened for their antioxidant activities.