A novel approach to contrast-induced nephrotoxicity: the melatonergic agent agomelatine


KARAMAN A., Diyarbakir B., DURUR-SUBASI I., KÖSE D., Ozbek-Bilgin A., Topcu A. , ...More

BRITISH JOURNAL OF RADIOLOGY, vol.89, no.1061, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 89 Issue: 1061
  • Publication Date: 2016
  • Doi Number: 10.1259/bjr.20150716
  • Title of Journal : BRITISH JOURNAL OF RADIOLOGY

Abstract

Objective: To study the potential nephroprotective role of agomelatine in rat renal tissue in cases of contrast-induced nephrotoxicity (CIN). The drug's action on the antioxidant system and proinflammatory cytokines, superoxide dismutase (SOD) activity, levels of glutathione (GSH) and malondialdehyde (MDA) and the gene expression of interleukin-6 (IL-6), tumour necrosis factor (TNF)-alpha and nuclear factor kappa B (NF-kappa B) was measured. Tubular necrosis and hyaline and haemorrhagic casts were also histopathologically evaluated.