NEW PYRIDINE DERIVATIVES AS ANTIUREASE INHIBITORS: SYNTHESIS AND THEIR EVALUATION FOR ANTIMICROBIAL ACTIVITIES
REVUE ROUMAINE DE CHIMIE, cilt.62, sa.3, ss.199-205, 2017 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 62 Sayı: 3
- Basım Tarihi: 2017
- Dergi Adı: REVUE ROUMAINE DE CHIMIE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.199-205
- Recep Tayyip Erdoğan Üniversitesi Adresli: Evet
Özet
6-Morpholin-4-ylpyridin-3-amine (3) gathered starting from morpholine by two steps was converted into the corresponding arylidenehydrazides through the reaction with several aromatic aldehydes. The treatment of compound 3 with phenylisothiocyanate generated N-(6-morpholin-4-ylpyridin-3-y1)-N-phenylthiourea (6). The synthesis of 1,3-thiazolidine (7) and 1,3-thiazole derivatives was performed from the reaction of 6 with 4-chlorophenacyl bromide and ethyl bromoacetate, respectively. All synthesized compounds were inspected for their antimicrobial and antiurease activites.