NEW PYRIDINE DERIVATIVES AS ANTIUREASE INHIBITORS: SYNTHESIS AND THEIR EVALUATION FOR ANTIMICROBIAL ACTIVITIES


Bektas H., Albay C., Mentese E. , DEMİRBAŞ N.

REVUE ROUMAINE DE CHIMIE, vol.62, no.3, pp.199-205, 2017 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 62 Issue: 3
  • Publication Date: 2017
  • Title of Journal : REVUE ROUMAINE DE CHIMIE
  • Page Numbers: pp.199-205

Abstract

6-Morpholin-4-ylpyridin-3-amine (3) gathered starting from morpholine by two steps was converted into the corresponding arylidenehydrazides through the reaction with several aromatic aldehydes. The treatment of compound 3 with phenylisothiocyanate generated N-(6-morpholin-4-ylpyridin-3-y1)-N-phenylthiourea (6). The synthesis of 1,3-thiazolidine (7) and 1,3-thiazole derivatives was performed from the reaction of 6 with 4-chlorophenacyl bromide and ethyl bromoacetate, respectively. All synthesized compounds were inspected for their antimicrobial and antiurease activites.