Association of paraoxonase-1 L55M and Q192R polymorphisms with PCOS risk and potential risk factors for atherosclerosis


Nalkiran H. , Sahin S. B. , Ayaz T. , Nalkiran I. , Guzel A. I. , Eldes T., ...More

BIOMARKERS IN MEDICINE, vol.13, no.4, pp.279-289, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 4
  • Publication Date: 2019
  • Doi Number: 10.2217/bmm-2018-0271
  • Title of Journal : BIOMARKERS IN MEDICINE
  • Page Numbers: pp.279-289
  • Keywords: atherosclerosis risk factors, body mass index, insulin resistance, metabolic syndrome, paraoxonase 1 gene, polycystic ovary syndrome, predictive marker, single nucleotide polymorphism, POLYCYSTIC-OVARY-SYNDROME, CORONARY-ARTERY-DISEASE, HIGH-DENSITY-LIPOPROTEIN, METABOLIC SYNDROME, GENE POLYMORPHISMS, ANDROGEN EXCESS, WOMEN, PREVALENCE, CRITERIA, PREDICTORS

Abstract

Aim: To examine the PON1-L55M and-Q192R polymorphisms for polycystic ovary syndrome (PCOS) risk in relation with atherosclerosis risk markers. Methods: Blood samples were collected from 203 women (PCOS [n = 151], control [n = 52]). Genomic DNA was extracted and RFLP method was performed following the amplifications of the target regions. Results: Individuals with 192QR/192RR genotypes had a 2.5-fold increased risk of representing PCOS compared with the individuals with 192QQ genotype. Q192R was more strongly associated with PCOS than previously suggested atherosclerosis risk markers. Q192R status and body mass index values in combination were established to be a significant predictor of PCOS (AUC: 0.655, p = 0.001). Conclusion: This is one of the first studies suggesting the use of combination biomarkers to better predict the risk of developing PCOS.