Is there any effect of lycopene’s preventing peritoneal adhesion formation in rats: an experimental study ¿Tiene el licopeno algún efecto en la prevención de la formación de adherencias peritoneales en ratas? Un estudio experimental
Cirugia y Cirujanos, vol.94, no.3, pp.293-300, 2026 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 94 Issue: 3
- Publication Date: 2026
- Doi Number: 10.24875/ciru.24000434
- Journal Name: Cirugia y Cirujanos
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, Directory of Open Access Journals, Biomedical Reference Collection: Corporate Edition (EBSCO)
- Page Numbers: pp.293-300
- Keywords: Adhesion, Lycopene, Peritoneum, Rat, Vascular endothelial growth factor
- Open Archive Collection: AVESIS Open Access Collection
- Recep Tayyip Erdoğan University Affiliated: Yes
Abstract
Objective: Effects of lycopene in prevention of intra-abdominal adhesion formation in a rat model. Methods: Twenty-eight rats were divided into four groups consisting of 7 rats each. Group 1 (only adhesion), Group 2 (adhesion + corn oil), Group 3 (adhesion + 5 mg/kg lycopene), Group 4 (adhesion + 20 mg/kg lycopene). Adhesion score, histopathology, vascular endothelial growth factor (VEGF) H-score, malondialdehyde (MDA), total antioxidant capacity, and VEGF values were measured. Results: There were significantly higher extent, severity, degree, and total adhesion scores in the control and corn-oil group than in the low lycopene and high lycopene group. VEGF H-scores were significantly lower in lycopene-given groups, regardless of dose. When the low lycopene and high lycopene groups were compared in terms of anti-VEGF H-score, no significant difference was observed. Malondialdehyde levels were statistically significantly lower in the control and high lycopene group. Conclusions: Biochemical parameters, histopathological examination, and adhesion scoring revealed that lycopene significantly reduced adhesion formation.