Serum apelin levels and cardiovascular diseases Serum Apelin Düzeyleri ve Kardiyovasküler Hastalıklar

Aşkın L., Askin H. S., tanrıverdi o., Özyıldız A. G., DUMAN H.

Northern Clinics of Istanbul, vol.9, no.3, pp.290-294, 2022 (ESCI) identifier identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 9 Issue: 3
  • Publication Date: 2022
  • Doi Number: 10.14744/nci.2021.33427
  • Journal Name: Northern Clinics of Istanbul
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Central & Eastern European Academic Source (CEEAS), Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.290-294
  • Keywords: Apelin, cardiomyocytes, inotropy, myocardial performance, PEPTIDE APELIN, CARDIAC-FUNCTION, HEART, APJ, CONTRACTILITY, SUSCEPTIBILITY, LOCALIZATION, POLYMORPHISM, PROGRESSION, MECHANISMS
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

Apelin is a G protein-linked receptor endogenous ligand, synthesized as a 77-amino acid pre-propeptide. Increased expression of apelin is present in many cardiovascular (CV) tissues, including cardiomyocytes. It is a peripheral vasodilator and one of the most potent stimulants of ventricular contraction. Apelin may be a valuable therapeutic for both blood pressure regulation and myocardial performance. More information is needed for the CV pathophysiology of apelin. We will discuss the importance of apelin level in CV diseases in this review.