Melatonin improves periodontitis-induced kidney damages by decreasing inflammatory stress and apoptosis in rats


KÖSE O., Bayrakdar S. K. , Unver B., ALTIN A., AKYILDIZ K., MERCANTEPE T., ...More

JOURNAL OF PERIODONTOLOGY, vol.92, no.6, pp.22-34, 2021 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 92 Issue: 6
  • Publication Date: 2021
  • Doi Number: 10.1002/jper.20-0434
  • Journal Name: JOURNAL OF PERIODONTOLOGY
  • Journal Indexes: Science Citation Index Expanded, Scopus, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database, DIALNET
  • Page Numbers: pp.22-34
  • Keywords: experimental periodontitis, kidney, matrix metalloproteinase(s), melatonin, oxidative stress, periodontal&#8208, systemic disease interactions, OXIDATIVE STRESS, CATHEPSIN-D, TISSUE, PATHOGENESIS, DISEASE, ALPHA, INDEX, MICE

Abstract

Background Two main aims of this animal study were to inspect the possible effects of periodontitis on the structure and functions of the kidneys and the therapeutic effectiveness of melatonin.