Effects of early administration of dexamethasone, N-acetylcysteine and aprotinin on inflammatory and oxidant-antioxidant status after lung contusion in rats


TÜRÜT H., Ciralik H., Kilinc M., Ozbag D., Imrek S. S.

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, vol.40, no.5, pp.521-527, 2009 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 5
  • Publication Date: 2009
  • Doi Number: 10.1016/j.injury.2008.05.001
  • Journal Name: INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.521-527
  • Keywords: Pulmonary contusion, Oxidant-antioxidant, Inflammation, Dexamethasone, N-Acetylcysteine, Aprotinin, BLUNT CHEST TRAUMA, PULMONARY CONTUSION, EXPERIMENTAL-MODEL, SECONDARY INJURY, RESUSCITATION, MACROPHAGE, CARDIOPULMONARY, REPERFUSION, MORTALITY, ISCHEMIA

Abstract

Introduction: This experimental setting was undertaken to elucidate and confirm the role of inflammatory and oxidant-antioxidant mechanisms on blunt injury induced moderate pulmonary contusion (PC). We intended to determine the effects of dexamethasone (DXM), N-acetylcysteine (NAC) and aprotinin (APR) in terms of their ability to diminish the consequences of acute lung injury due to PC.