Research Information System
KSU TARIM VE DOGA DERGISI-KSU JOURNAL OF AGRICULTURE AND NATURE, vol.28, no.4, pp.903-913, 2025 (ESCI, TRDizin)
Over the past decade, antibiotic resistance has increased at an unprecedented rate, posing a serious challenge to healthcare systems worldwide. Research indicates that this resistance issue, which is projected to cause significant loss of life by the 2050s, is particularly alarming. Consequently, alternative methods to effective antibiotics are being explored to combat resistance. Rubus fruticosus L., commonly known as blackberry, is a shrub plant famous for its fruit. This fruit holds significant medicinal, cosmetic, and nutritional value. In our study, methanol, ethyl acetate, ethanol, and hexane extracts of Rubusfruticosus fruit from the Rize region were screened for their antimicrobial and quorum-sensing activities. Antimicrobial activity was investigated using the agar diffusion method against various Gram-negative and Grampositive bacteria, as well as two Candida species. Anti-quorum sensing and antibiofilm activities were evaluated using Chromobacterium violaceum ATCC 12472 and Pseudomonas aeruginosa PAO1. The results showed that the methanol extract of Rubus fruticosus exhibited antimicrobial activity, while the ethanol extract demonstrated antibiofilm and anti-swarming activities. These findings suggest that Rubus fruticosus has the potential to be used as a natural agent in combating antimicrobial resistance.