Evaluation of Microsatellite Instability in Colorectal Adenomas and Carcinomas by Immunohistochemistry and a Comparison of Histopathological Features

YILMAZ R., Bedir R., Akdogan R. A., PERGEL A.

EUROPEAN JOURNAL OF THERAPEUTICS, cilt.25, sa.1, ss.28-38, 2019 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.5152/eurjther.2018.582
  • Dergi Adı: EUROPEAN JOURNAL OF THERAPEUTICS
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.28-38
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

Objective: Approximately 15% of sporadic colorectal carcinomas (CRCs) develop along the microsatellite instability (MSI) pathway. In this study, we compared the MLH1, MSH2, Ki-67, and p53 immunostaining properties with histopathological features of colorectal adenomas and CRCs.