Evaluation of Microsatellite Instability in Colorectal Adenomas and Carcinomas by Immunohistochemistry and a Comparison of Histopathological Features

YILMAZ R., Bedir R., Akdogan R. A., PERGEL A.

EUROPEAN JOURNAL OF THERAPEUTICS, vol.25, no.1, pp.28-38, 2019 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 1
  • Publication Date: 2019
  • Doi Number: 10.5152/eurjther.2018.582
  • Journal Name: EUROPEAN JOURNAL OF THERAPEUTICS
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.28-38
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

Objective: Approximately 15% of sporadic colorectal carcinomas (CRCs) develop along the microsatellite instability (MSI) pathway. In this study, we compared the MLH1, MSH2, Ki-67, and p53 immunostaining properties with histopathological features of colorectal adenomas and CRCs.