Synthesis and Biological Evaluation of Some Succinimide Hybrid Molecules

Yilmaz F., Mentese E., Baltas N.

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, vol.45, no.6, pp.575-584, 2019 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 6
  • Publication Date: 2019
  • Doi Number: 10.1134/s1068162019060402
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.575-584
  • Keywords: pyrrolidine-2,5-diones, alpha-glucosidase, coumarin, isatin, furan, antioxidant activity, THIAZOLE DERIVATIVES, COUMARIN DERIVATIVES, INHIBITORS, BENZIMIDAZOLE, CATALYST, NITROGEN, DOCKING
  • Recep Tayyip Erdoğan University Affiliated: Yes


In this study, a new series of succinimide hybrid molecules containing isothiocyanate, coumarin, isatin, and furan moieties was synthesized and screened for alpha-glucosidase and antioxidant activities. Preliminary results revealed that all molecules showed good alpha-glucosidase inhibition effectiveness. Antioxidant activities of the hybrid molecules were determined using cupric reducing antioxidant capacity (CUPRAC) and ferric reducing antioxidant power (FRAP) assays. Also, the radical scavenging activities of the synthesized compounds were assayed by using The results showed that all compounds exhibited moderated to high scavenging activity.