Some characteristics of new and innovative COX inhibitor derivatives: Potent hCA-I and hCA-II inhibitors supported by molecular docking studies


Karakilic E., Alim Z., EMİRİK M. , Baran A.

APPLIED ORGANOMETALLIC CHEMISTRY, 2021 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2021
  • Doi Number: 10.1002/aoc.6537
  • Title of Journal : APPLIED ORGANOMETALLIC CHEMISTRY
  • Keywords: DNA-binding, enzyme, inhibitors, metal complexes, molecular docking, CARBONIC-ANHYDRASE INHIBITORS, LANGMUIR-BLODGETT-FILMS, PHTHALOCYANINE COMPLEXES, PHOTOCHEMICAL PROPERTIES, COPPER PHTHALOCYANINE, ZINC PHTHALOCYANINE, DUAL INHIBITION, DNA-BINDING, METAL, CELL

Abstract

In this study, two novel metallophthalocyanines (ZnPc and CoPc) were synthesized using the corresponding metal salts 4-(4-(4-[4-chlorophenyl]-5-methylisoxazol-3-yl)phenoxy)-phthalonitrile (11), prepared from the reaction of 4-nitrophthalonitrile and 4-(4-[4-chlorophenyl]-5-methylisoxazol-3-yl)phenol (9). These metallophthalocyanines (MPcs) showed quite solubility in organic solvents such as dichloromethane (DCM), tetrahydrofuran (THF), dimethyl formamide (DMF), and dimethylsulfoxide (DMSO). The novel compounds 11a and 11b have been characterized using their UV-Vis, FT-IR, H-1 NMR, C-13 NMR, X-Ray, and MALDI-TOF mass spectra. Supporting information cocerning with the study has been supplied. Photochemical, photophysical, and cyclic voltagram properties of these novel 4-(4-(4-[4-chlorophenyl]-5-methylisoxazol-3-yl)phenoxy substituted metallophthalocyanines (11a and 11b) were determined in DMF. DNA binding, metal chelating effect assay, and DPPH [2,2-diphenyl-1-picrylhydrazyl hydrate] radical scavenging assay and electrochemical studies of MPcs were investigated. Further, the inhibitory effects of the COX-inhibitor based novel metallophthalocyanines (11a and 11b) and their ligands (10 and 11) were examined on human erythrocyte carbonic anhydrase I (hCA-I) and II (hCA-II) isoenzymes, and the synthesized molecules exhibited very strong inhibitory effects on both isoforms. In addition, the hCA-I and hCA-II inhibition potential of Zn (II) and Co (II) Phthalocyanine complexes was supported by molecular docking studies. The binding interaction of metallophthalocyanines complexes 11a, 11b enzymes were analyzed in detail.