Usefullness of Serum Insulin-Like Growth Factor (IGF-1) and Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3) for Colorectal Cancer Diagnosis

Yilmazi O., Koruk I., Cayir K., KORUK M., Yilmaz A.

UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI, vol.19, no.1, pp.23-27, 2009 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 1
  • Publication Date: 2009
  • Journal Name: UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.23-27
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

Insulin-like growth factor (IGF-I) is a potent mitogen and an anti-apoptotic agent which is regulated by insulin-like growth factor binding protein-3 (IGFBP-3). IGFBP-3 carries IGF-I through the bloodstream to the target tissues and protects it from proteolytic degradation. IGFBP-3 reduces tumorigenic potential of colon cancer cells in vitro. IGFBP-3 may inhibit target cells directly. In the present study, we assessed whether serum levels of IGF-I and IGFBP-3 could be used as tumor markers in patients with colorectal cancers and evaluated its relationship with known tumor markers, carcinoembryogenic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9).