The present study examines the roles of the meaning in life and the life satisfaction on university students' Career Decision Self-Efficacies (CDSE). Turkish university students [n = 440, 332 females (75.5%) and 108 males (24.5%)] aged 18-21 years [the mean age of 20.90 years (sd = 1.97)] were recruited from a state university located in the Eastern Black Sea Region in Turkey through a convenient sampling method. In the study, The Career Decision SelfEfficacy Scale- Short Form (Isik 2010), the Meaning in Life Scale (Demirbas 2010) and the Life Satisfaction Scale (Koker 1991) were used as instruments. The collected data were analyzed through the Pearson product-moment correlation coefficient technique and multiple linear regression analysis. Pearson correlations revealed that life satisfaction (r = 0.446, p < 0.01) and the meaning in life (r = 0.167, p < 0.01) were positively related to CDSE. Also, multiple linear regression revealed that life satisfaction and the meaning in life are significant predictors of CDSE.