Akademik Veri Yönetim Sistemi
Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, cilt.12, sa.1, ss.117-124, 2025 (Hakemli Dergi)
Aim
Our aim was to assess the correlation between minor salivary gland pathology and the results of Schirmer and serological tests conducted during the diagnosis of primary Sjögren's syndrome (pSS).
Method
A total of 41 patients who were diagnosed with pSS after having serological tests, minor salivary gland biopsy and Schirmer test performed at our institution at the time of diagnosis between June 2018 and July 2023 were included in the study. Focus score, atrophy and fibrosis values were scored in biopsy samples. The relationship between histopathological findings and clinical, Schirmer test and serological tests was evaluated.
Results
Of the 41 patients, 38 were female (92.7%), 3 (7%) were male, and the average age was 55.54 ± 14.06. In patients with focal score≥1, antinuclear antibody value≥1/320 (42.9%), rheumatoid factor positivity (28.6%), anti Sjögren's syndrome (SS) A/SSB positivity (76.2%, 38.1%) ) was detected at a higher rate. Additionally, acinar atrophy and fibrosis were higher in patients with focus score≥1, and there was a significant relationship between fibrosis (p<0.008). A significant correlation was detected between age with acinar atrophy and fibrosis score1≥ (p=0.030, p=0.006) and between dry mouth with fibrosis (p=0.008). In multivariate analysis, schimer test positivity in focal score was observed as an independent risk factor (OR = 22.531, 95%CI 1.369–370.174).
Conclusion
In our study, a high focus score was found to be correlated with positive serological tests and impaired exocrine functions, and a positive Schirmer test was found to have an increasing effect on the focus score.