Aim: Interatrial block (IAB) is an electrocardiographic (ECG) panern that indicates a delay in the conduc5on between the right and le` atria, through Bachmann’s bundle. Any delay in atrial conduc5on detected on the ECG as a P-wave dura5on longer than 120 msn is defined as IAB. The significance of this delay arises from its correla5on with atrial arrhythmias, thromboembolic events and cardiovascular mortality. The Fibrosis-4 (FIB-4) index is a non-invasive scoring tool used to quan5fy the extent of liver fibrosis in individuals with non-alcoholic fany liver disease (NAFLD). Growing evidence indicates that pa5ents with NAFLD are at substan5al risk for the development of hypertension, coronary heart disease, cardiomyopathy, and cardiac arrhythmias, which ul5mately lead to a higher incidence of cardiovascular morbidity and mortality. The aim of the current study is to examine the poten5al correla5on between IAB and FIB-4 index in non-alcoholic popula5on.
Materials-Methods: This cross-sec5onal study included a cohort of 248 (110 of them were women) non- alcoholic outpa5ents who admined to the cardiology clinic. The analysis of the pa5ents' individual FIB-4 index were conducted u5lizing clinical and labaratuary data: FIB-4 Score = (Age x AST) / (Platelets x √(ALT)). Pa5ents were divided into two groups according to the presence or absence of interatrial block on ECG. Following a minimum fas5ng 5me of 12 hours, laboratory parameters were acquired using peripheral venous sample, and electrocardiographic measurements, clinical and medica5on data were recorded.
Results: The univariate logis5c regression analysis revealed significant associa5ons between age (p=0.003), FIB-4 index (p=0.025), beta-blocker usage (p=0.01), C-reac5ve protein (CRP, p=0.047), and low-density lipoprotein (LDL, p=0.042) with IAB. In the context of mul5variate logis5c regression analysis, there existed a significant independent rela5onship between IAB with LDL (OR: 0.989, 95% CI: 0.979-1.000, p=0.046), CRP (OR: 3.804, 95% CI: 1.180-12.257, p=0.025), and FIB-4 index (OR: 1.693, 95% CI: 1.018-2.816, p=0.043).
Conclusion: The IAB may have a dis5nct correla5on with NAFLD. Extensive inves5ga5ons should validate this link, since IAB can serve as a useful ECG tool for monitoring pa5ents before the onset of clinical signs related to liver fibrosis.

Keywords: Interatrial block, non-alcoholic fany liver disease, FIB-4 index