Synthesis of novel tetra-substituted benzimidazole compounds containing certain heterostructures with antioxidant and anti-urease activities

Karaali N., Aydin S., Baltas N., Mentese E.

JOURNAL OF HETEROCYCLIC CHEMISTRY, vol.57, no.4, pp.1806-1815, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 4
  • Publication Date: 2020
  • Doi Number: 10.1002/jhet.3905
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), Chimica, EMBASE
  • Page Numbers: pp.1806-1815
  • Recep Tayyip Erdoğan University Affiliated: Yes


A new series of 5,6-dimethyl-2-phenyl-1H-benzimidazole derivatives was synthesized. The antioxidant activities of the synthesized compounds were determined according to the cupric reducing antioxidant capacity (CUPRAC), ABTS, and DPPH assays. Many of the target compounds showed good antioxidant activity. Among these compounds, it has been determined that the carbothioamide and 1,2,4-triazole derivatives had a very good antioxidant capacity. Also, all compounds were screened for in vitro inhibitory activity against Jack bean urease. Among the synthesized molecules, the starting compound, acetate, and acetohydrazide derivatives (with IC50 values 12.02, 11.40, and 8.04 mu g/mL, respectively) had a higher inhibitory effect on urease and exhibited a lower IC50 values than acetohydroxamic acid (IC50: 20.50 mu g/mL) and thiourea (IC50: 14.04 mu g/mL) as a reference inhibitors.