The effect of hesperidin and quercetin on oxidative stress, NF-kappa B and SIRT1 levels in a STZ-induced experimental diabetes model

İSKENDER, HATİCE; DOKUMACIOĞLU, EDA; Sen, Tugba; Ince, Imran; KANBAY, YALÇIN; Saral, SİNAN

doi:10.1016/j.biopha.2017.03.102

The effect of hesperidin and quercetin on oxidative stress, NF-kappa B and SIRT1 levels in a STZ-induced experimental diabetes model

İSKENDER H., DOKUMACIOĞLU E., Sen T. M., Ince I., KANBAY Y., Saral S.

BIOMEDICINE & PHARMACOTHERAPY, vol.90, pp.500-508, 2017 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 90
Publication Date: 2017
Doi Number: 10.1016/j.biopha.2017.03.102
Journal Name: BIOMEDICINE & PHARMACOTHERAPY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.500-508
Keywords: Diabetes, Hesperidin, NF-kappa B, Oxidative stress, Quercetin, Sirtuin-1, FLAVONOID ANTIOXIDANT, NEPHROPATHY, INHIBITION, BETA, RATS, HYPERGLYCEMIA, TRANSCRIPTION, ACTIVATION, PREVENTS, LIVER
Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

Objective: The aim of this study is to investigate the roles of SIRT1 and NF-kappa B in the pathogenesis of diabetes mellitus in rats with STZ-induced diabetes and determine the effects of hesperidin and quercetin on oxidative stress and on the levels of SIRT1 and NF-kappa B.