3 RD INTERNATIONAL CONGRESS OF TURKISH NEUROENDOCRINOLOGY SOCIETY, Malatya, Türkiye, 29 Haziran - 01 Eylül 2018, ss.0-36
The postmenopausal period is associated with body weight gain in women. Body weight gain is also a common phenomenon in ovariectomized (Ovx) rats. In clinical and experimental studies, tea polyphenols have been reported to cause weight loss through thermogenesis and lipid peroxidation. However, the effect of white tea on Ovx-induced body weight changes is unknown. For this purpose, the role of long-term consumption of white tea (WT) on body weight gain in the menopausal model rats in the present study was examined. In the study, 32 female rats were used in the range of 250-300 gr. Bilateral ovariectomy procedures were performed to sixteen rats. Then, the rats were grouped into sham, Ovx, white tea (WT) and Ovx+WT, respectively, as 8 in each group. WT was administered for 12 weeks with 0.5% drinking water. As a result of the experiment, body weight changes of rats, serum estradiol (E2), leptin and TNF-α levels were evaluated. Statistical analysis of body weights of groups used variance analysis in repeated measures. Data were analysed with one-way ANOVA. There was significant difference between the body weights of Ovx and Ovx+WT group (p<0.001). Body weight of the Ovx + WT group is lower than Ovx group. Serum E2 levels in Ovx group was found low compared to control group. Serum leptin levels in Ovx and WT groups were significantly decreased compared to control group (p<0.01, p<0.05, respectively). Serum TNF-α levels in Ovx group was significantly increased compared to control group (p<0.01), but there was no significant in serum TNFα between control and WT groups (p>0.05). The increase in body weight due to menopause can be limited by the addition of white tea to the diet. This effect can be regulated by both hormone and proinflammatory cytokine levels.