Akademik Veri Yönetim Sistemi
15 th International Congress of Histochemistry and Cytochemisrty, Antalya, Türkiye, 18 - 21 Mayıs 2017, (Özet Bildiri)
Introduction & OBJECTIVES: Allantoin has numerous widely cited pharmacological purposes, including tissue regeneration and cell
proliferation. Axonal regeneration is possible following the axonal injury. In this context, neuroprotective agents may increase the axonal
regeneration. In this study; we investigated the possible functional and morphological efects of allantoin on sciatic nerve regeneration.
Materials & METHODS: The experimental injury model was designed with a force of 50 Newtons during 5 seconds with the help of pliers
on the right sciatic nerve of rats in test group. Allantoin was administered intraperitoneally (10 mg/kg) to the test groups during 30
days following injury. Animals were sacriiced at the end of 30 days and nerve samples taken from animals were evaluated in terms of
myelinated axon number, myelin sheath thickness, and axon diameter stereologically, in addition to immuhistochemical observation. The
Electromiyography (EMG) and Sciatic Function Index (SFI) tests also were performed.
RESULTS: According to stereological evaluations no diferences were found between allantoin given group and only crush group in base
of myelinated axon number, myelin thickness, axon diameter and myelin thickness/axon diameter ratio. On the other hand, there were
signiicant diferences between two groups in increasing way in point of both amplitude and S100 expression levels.
CONCLUSIONS: The i.p. administration of allantoin may have beneicial efect on nerve healing.