Comparison of three different combination therapies in the treatment of human brucellosis

Ersoy Y., Sonmez E., Tevfik M., But A.

TROPICAL DOCTOR, vol.35, no.4, pp.210-212, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 4
  • Publication Date: 2005
  • Doi Number: 10.1258/004947505774938765
  • Journal Name: TROPICAL DOCTOR
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.210-212
  • Recep Tayyip Erdoğan University Affiliated: No


The efficacy and tolerability of three different combination treatment regimens in human brucellosis were compared in 118 uncomplicated patients enrolled in a prospective study between May 1997 and December 2002. Brucellosis was diagnosed using standard clinical and microbiological findings. Patients with central nervous system involvement, spondylitis, endocarditis or children under 16 years of age were excluded from the study. Patients were randomly assigned to receive 400 mg of ofloxacin plus 600 mg of rifampicin (OR, n = 41),200 mg of doxycycline plus 600 mg of rifampicin (DR, n = 45) or 1 g intramuscularly streptomycin (administered for three weeks) plus 200 mg doxycycline (DS, n = 32) daily for 6 weeks. All patients were followed up at least 6 months after cessation of therapy.