Electrochemical Detection of Epinephrine Based on a Screen-printed Electrode Modified with NiO−ERGO Nanocomposite Film

Gunes O., Sarilmaz A., Bas S. Z., Ozmen M., Ozel F., Ersoz M.

Electroanalysis, cilt.33, sa.12, ss.2460-2468, 2021 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 12
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1002/elan.202100394
  • Dergi Adı: Electroanalysis
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Applied Science & Technology Source, BIOSIS, Chemical Abstracts Core, Chimica, Communication Abstracts, Metadex, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.2460-2468
  • Anahtar Kelimeler: electrochemical reduction, electrochemical sensor, Epinephrine, NiO, reduced graphene oxide
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Hayır

Özet

This study presents a new electrochemical sensor (NiO−ERGO/SPE) for sensitive and selective detection of epinephrine (EPI) on the screen-printed electrode (SPE) which is modified with a nanocomposite film consisting of electrochemically reduced graphene oxide and NiO nanoparticles. After surface functionalization, structural and electrochemical characterization of NiO−ERGO film, DPV signals of NiO−ERGO/SPE towards the oxidation of EPI exhibited a linear correlation in the concentration range of 0.025 μM to 175 μM with a detection limit of 0.015 μM, which reveals NiO−ERGO film is manifested a good electrocatalytic activity for EPI detection compared with the previous reports. The selectivity of NiO−ERGO film was also tested on a very wide scale of possible interferents (ascorbic acid, uric acid, dopamine, lactic acid, phenylalanine, tyrosine, tryptophan, Li+, Na+, K+, Ca2+, and Zn2+). Moreover, to evaluate the applicability of the proposed sensor for real sample analysis, NiO−ERGO/SPE was successfully utilized for the determination of EPI in pharmaceutical samples.