Development of Electrochemical Cytosensor Using LN-18 Cells on Fibronectin Coated Electrospun PAN Nanofibers on ITO Surface

Kurt Ş., Bal Altuntaş D., Sevim Nalkıran H., Aslan S., Koçak Ç., Mamuk A. E., ...Daha Fazla

18th Nanoscience and Nanotechnology Conference, İstanbul, Türkiye, 26 Ağustos - 28 Ekim 2024, ss.92

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: İstanbul
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.92
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

Nanobiotechnology is very important in cancer research. Glioblastoma is the most common and

aggressive primary malignant brain tumor. In recent years, nanostructured materials have attracted

considerable attention due to their unique properties resulting from their size-dependent

structural/electrical/optical behaviors, and they have become appealing materials in many areas such

as, cancer research, tissue engineering, drug transfer and biosensor . Nanofibers, on the other hand,

provide advantages with their physical and chemical properties in nano dimensions in solving these

problems which are difficult to overcome in macro dimensions. In this study, electrospun PAN and

PAN/C500 nano-fibers on ITO (Indium Tin Oxide) coated glass surface were prepared and coated with

fibronectin to create a 3D glioblastoma tumor model using LN-18 cells. The cells in the model were

evaluated morphologically by fluorescence microscopy and electrochemical measurements were made

performed.