DESIGN, SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF SOME AZOLE DERIVATIVES


Basoglu S., Yolal M., Demirci S., DEMİRBAŞ N., BEKTAŞ H., Karaoglu S. A.

ACTA POLONIAE PHARMACEUTICA, vol.70, no.2, pp.229-236, 2013 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 70 Issue: 2
  • Publication Date: 2013
  • Journal Name: ACTA POLONIAE PHARMACEUTICA
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.229-236
  • Keywords: furan-2-carbohydrazide, 1,2,4-triazole, Mannich base, Schiff base, antimicrobial activity, BIOLOGICAL EVALUATION, ANTITUMOR ACTIVITIES, SCHIFF-BASES, ONE-POT, AGENTS, 1,2,4-TRIAZOLES, MANNICH, ANTAGONIST, MOIETY

Abstract

Three new 1,3,4-oxadiazole, 1,3-thiazolidine and 1,2,4-triazole derivatives were obtained starting from furan-2-carbohydrazide. Then, 1,2,4-triazole compound was converted to the corresponding Mannich bases using several secondary amines including piperidine, piperazine, morpholine or thiomorpholine moiety. The synthesis of 5-(furan-2-yl)-4-{[(4-methoxyphenyl)methylidene]amino}-4H-1,2,4-triazole-3-thiol (XIII) was performed starting from furan-2-carbohydrazide by three steps. The structures of the synthesized compounds were well characterized by elemental analyses, IR, H-1 NMR, C-13 NMR and mass spectral studies. Newly synthesized compounds were screened for their antimicrobial activities and some of them displayed activity against the tested microorganisms.