Pott's disease and hypercalcemia in a patient with rheumatoid arthritis receiving methotrexate monotherapy


ZORLU M., KISKAÇ M., KARATOPRAK C., ÇAKIRCA M., Yavuz E., ÇETİN G., ...Daha Fazla

INDIAN JOURNAL OF PHARMACOLOGY, cilt.45, ss.631-633, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 45 Konu: 6
  • Basım Tarihi: 2013
  • Doi Numarası: 10.4103/0253-7613.121385
  • Dergi Adı: INDIAN JOURNAL OF PHARMACOLOGY
  • Sayfa Sayıları: ss.631-633

Özet

Methotrexate (MTX) may have adverse effects on multiple organs and system. A few cases of pulmonary tuberculosis in-patients with rheumatoid arthritis (RA) while receiving MTX monotherapy has been reported in the literature. We submit a case of vertebral tuberculosis with hypercalcemia in a patient receiving MTX monotherapy. Patient with RA taking MTX for 15 years developed pancytopenia, skin necrosis, tuberculous spondylodiscitis and hypercalcemia. The present case showed adverse effects of MTX therapy may occur even after years of continuous treatment. Due to pancytopenia in older patients, life-threatening tuberculosis at unusual sites may develop.