Microwave-Assisted Synthesis and Biological Evaluation of Some Benzimidazole Derivatives Containing a 1,2,4-Triazol Ring

Mentese E., Karaali N., Yilmaz F., Ulker S., KAHVECİ B.

ARCHIV DER PHARMAZIE, vol.346, no.7, pp.556-561, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 346 Issue: 7
  • Publication Date: 2013
  • Doi Number: 10.1002/ardp.201300050
  • Journal Name: ARCHIV DER PHARMAZIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.556-561
  • Keywords: Antioxidant activity, Lipase inhibition, 1, 2, 4-Triazole, 2-(4-(Trifluoromethyl)phenyl)-1H-benzo[d]imidazole, VITRO ANTIMICROBIAL ACTIVITY, ANTIOXIDANT
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

A new series of 2-(4-(trifluoromethyl)phenyl)-1H-benzo[d]imidazole derivatives containing a 1,2,4-triazole ring were synthesized via microwave technique. This efficient procedure provides pure products within a few minutes. The newly synthesized compounds were confirmed by H-1 NMR and C-13 NMR spectra and they were screened for their lipase inhibition and antioxidant activities. Compounds 4a, 4b, 5a, and 5b showed very good scavenging activity.