Microwave-Assisted Synthesis and Biological Evaluation of Some Benzimidazole Derivatives Containing a 1,2,4-Triazol Ring


Mentese E. , Karaali N. , Yilmaz F. , Ulker S., KAHVECİ B.

ARCHIV DER PHARMAZIE, cilt.346, sa.7, ss.556-561, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 346 Konu: 7
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1002/ardp.201300050
  • Dergi Adı: ARCHIV DER PHARMAZIE
  • Sayfa Sayıları: ss.556-561

Özet

A new series of 2-(4-(trifluoromethyl)phenyl)-1H-benzo[d]imidazole derivatives containing a 1,2,4-triazole ring were synthesized via microwave technique. This efficient procedure provides pure products within a few minutes. The newly synthesized compounds were confirmed by H-1 NMR and C-13 NMR spectra and they were screened for their lipase inhibition and antioxidant activities. Compounds 4a, 4b, 5a, and 5b showed very good scavenging activity.