IRANIAN JOURNAL OF KIDNEY DISEASES, vol.9, no.3, pp.221-229, 2015 (Journal Indexed in SCI)
Article / Article
Title of Journal :
IRANIAN JOURNAL OF KIDNEY DISEASES
methotrexate, infliximab, nephrotoxicity, carbonic anhydrase, adenosine deaminase, ADENOSINE-DEAMINASE ACTIVITY, CARBONIC-ANHYDRASE-II, NITRIC-OXIDE, REPERFUSION, EXTRACT, DAMAGE, LEVEL, MALONDIALDEHYDE, EXPRESSION, REDUCTION
Introduction. Methotrexate, an antagonist of folic acid used in the treatment of many cancers and inflammatory diseases, is associated with side effects that limit its usage. Infliximab has been reported to have a protective effect against nephrotoxicity induced by some drugs and ischemic reperfusion. We aimed to investigate whether infliximab has a protective effect against methotrexate-induced nephrotoxicity.