Effect of Infliximab on Renal Injury Due to Methotrexate in Rat

KIRBAS A., Cure M. C., Kalkan Y., Cure E., TÜMKAYA L., Sahin O. Z., ...More

IRANIAN JOURNAL OF KIDNEY DISEASES, vol.9, no.3, pp.221-229, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 3
  • Publication Date: 2015
  • Journal Name: IRANIAN JOURNAL OF KIDNEY DISEASES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.221-229
  • Keywords: methotrexate, infliximab, nephrotoxicity, carbonic anhydrase, adenosine deaminase, ADENOSINE-DEAMINASE ACTIVITY, CARBONIC-ANHYDRASE-II, NITRIC-OXIDE, REPERFUSION, EXTRACT, DAMAGE, LEVEL, MALONDIALDEHYDE, EXPRESSION, REDUCTION
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

Introduction. Methotrexate, an antagonist of folic acid used in the treatment of many cancers and inflammatory diseases, is associated with side effects that limit its usage. Infliximab has been reported to have a protective effect against nephrotoxicity induced by some drugs and ischemic reperfusion. We aimed to investigate whether infliximab has a protective effect against methotrexate-induced nephrotoxicity.