IRANIAN JOURNAL OF KIDNEY DISEASES, vol.9, no.3, pp.221-229, 2015 (SCI-Expanded)
Article / Article
IRANIAN JOURNAL OF KIDNEY DISEASES
Science Citation Index Expanded (SCI-EXPANDED), Scopus
methotrexate, infliximab, nephrotoxicity, carbonic anhydrase, adenosine deaminase, ADENOSINE-DEAMINASE ACTIVITY, CARBONIC-ANHYDRASE-II, NITRIC-OXIDE, REPERFUSION, EXTRACT, DAMAGE, LEVEL, MALONDIALDEHYDE, EXPRESSION, REDUCTION
Recep Tayyip Erdoğan University Affiliated:
Introduction. Methotrexate, an antagonist of folic acid used in the treatment of many cancers and inflammatory diseases, is associated with side effects that limit its usage. Infliximab has been reported to have a protective effect against nephrotoxicity induced by some drugs and ischemic reperfusion. We aimed to investigate whether infliximab has a protective effect against methotrexate-induced nephrotoxicity.