Effects of Turkish propolis on expression of hOGG-1 and NEIL-1

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Turan I., DEĞER O., ALİYAZICIOĞLU Y., DEMİR S., Kilinc K., Sumer A.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.45, no.4, pp.804-811, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 4
  • Publication Date: 2015
  • Doi Number: 10.3906/sag-1406-98
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.804-811
  • Keywords: Propolis, DNA repair, NEIL-1, hOGG-1, comet assay, antigenotoxic effect, DNA-DAMAGE, POLYPHENOLIC COMPOUNDS, COMET ASSAY, REPAIR, GLYCOSYLASE, FLAVONOIDS, CELLS, ACID
  • Recep Tayyip Erdoğan University Affiliated: Yes


Background/aim: Propolis is a bee product with antioxidative, antimutagenic, and other beneficial properties, and it is used as a natural drug. It is rich in polyphenolic compounds. Its composition varies depending on the particular geographical region. Oxidative stress is caused by an imbalanced free radical production and antioxidant system. The effects of flavonoids on the expression of DNA repair enzymes have been examined previously; however, no study has investigated the effects of propolis. This study investigated the effects of ethanolic extracts of Turkish propolis (EEP) on the expression of DNA repair enzymes.