Biochemical and histopathologic analysis of the effects of periodontitis on left ventricular heart tissues of rats

Kose O., Arabaci T., Gedikli S., Eminoglu D. O., Kermen E., Kizildag A., ...More

JOURNAL OF PERIODONTAL RESEARCH, vol.52, no.2, pp.176-185, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 52 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.1111/jre.12380
  • Journal Name: JOURNAL OF PERIODONTAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.176-185
  • Keywords: animal model, heart failure, inflammation, myosin heavy chain, periodontal disease, C-REACTIVE PROTEIN, CARDIOVASCULAR-DISEASE, RISK-FACTORS, ENDOTHELIAL DYSFUNCTION, MYOCARDIAL-INFARCTION, KAPPA-B, INFLAMMATION, HYPERTROPHY, ATHEROSCLEROSIS, INTERLEUKIN-6
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

Background and ObjectiveCurrent epidemiological works have suggested that chronic infections, such as periodontitis, are associated with an increased risk of cardiovascular diseases, including hypertrophy and heart failure. However, mechanisms behind the association are not known. The aim of this study was to evaluate the effects of periodontitis on the serum lipid levels, inflammatory marker levels and left ventricular heart muscle tissues of rats.