Biochemical and histopathologic analysis of the effects of periodontitis on left ventricular heart tissues of rats


Kose O. , Arabaci T., Gedikli S., Eminoglu D. O. , Kermen E., Kizildag A., ...More

JOURNAL OF PERIODONTAL RESEARCH, vol.52, no.2, pp.176-185, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 52 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.1111/jre.12380
  • Title of Journal : JOURNAL OF PERIODONTAL RESEARCH
  • Page Numbers: pp.176-185
  • Keywords: animal model, heart failure, inflammation, myosin heavy chain, periodontal disease, C-REACTIVE PROTEIN, CARDIOVASCULAR-DISEASE, RISK-FACTORS, ENDOTHELIAL DYSFUNCTION, MYOCARDIAL-INFARCTION, KAPPA-B, INFLAMMATION, HYPERTROPHY, ATHEROSCLEROSIS, INTERLEUKIN-6

Abstract

Background and ObjectiveCurrent epidemiological works have suggested that chronic infections, such as periodontitis, are associated with an increased risk of cardiovascular diseases, including hypertrophy and heart failure. However, mechanisms behind the association are not known. The aim of this study was to evaluate the effects of periodontitis on the serum lipid levels, inflammatory marker levels and left ventricular heart muscle tissues of rats.