Akademik Veri Yönetim Sistemi
IRANIAN JOURNAL OF KIDNEY DISEASES, cilt.19, sa.6, ss.351-360, 2025 (SCI-Expanded, Scopus)
Introduction. Amoxicillin/Clavulanate (A/C) is a widely used antibiotic that can induce oxidative stress and renal apoptosis through reactive oxygen species (ROS). Mumijo extract (FA), known for its antioxidant and anti-inflammatory properties, has shown promise in mitigating such damage. This study aims to evaluate the efficacy of FA in protecting against A/C induced renal tissue damage in rats. Methods. The study included 28 Wistar albino rats, divided into four groups: Sham (saline), A/C (10 mg/kg/day), FA (100 mg/ kg/day), and A/C+FA. A/C and FA were administered orally for 21 days. Renal function markers (urea, creatinine), oxidative stress parameters (TAS, TOS, MDA), and histopathological findings were analyzed. Bax and Bcl-2 protein expressions were assessed to evaluate apoptosis. Results. A/C administration significantly increased renal urea, creatinine, TOS, and MDA levels while reducing TAS (P < .05). Histopathological analysis revealed tubular dilatation, degeneration, and inflammation in the A/C group. FA supplementation in the A/C+FA group significantly reduced oxidative stress markers and improved TAS levels, histopathological scores, and apoptosis indicators (increased Bcl-2 and reduced Bax expressions). FA alone demonstrated no adverse effects on renal parameters. Conclusion. FA effectively mitigates A/C-induced oxidative stress and renal apoptosis, preserving tissue integrity and function. These findings suggest FA as a potential therapeutic agent for managing drug-induced nephrotoxicity.