Impaired heart rate variability as a marker of cardiovascular autonomic dysfunction in multiple sclerosis

Tombul T., Anlar O., Tuncer M., Huseyinoglu N., Eryonucu B.

ACTA NEUROLOGICA BELGICA, vol.111, no.2, pp.116-120, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 111 Issue: 2
  • Publication Date: 2011
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.116-120
  • Recep Tayyip Erdoğan University Affiliated: Yes


Multiple sclerosis (MS) can cause alterations in autonomic cardiovascular functions. We aimed to investigate the correlation of disease activity and disability with heart rate variability (HRV) of cardiovascular autonomic dysfunction (CAD) demonstrated by 24-h Holter monitorization. Thirty-four patients with clinically active relapsing-remitting MS, age 33.8 +/- 7.6 years, were studied. Twenty healthy volunteers served as controls. The time domain long-term HRV parameters were recorded by a digicorder recorder calculated by ambulatory electrocardiograms.