Microwave-assisted synthesis of some new coumarin derivatives including 1,2,4-triazol-3-one and investigation of their biological activities

KAHVECİ B., Yilmaz F., Mentese E., Ulker S.

CHEMISTRY OF HETEROCYCLIC COMPOUNDS, vol.51, no.5, pp.447-456, 2015 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 5
  • Publication Date: 2015
  • Doi Number: 10.1007/s10593-015-1714-5
  • Journal Name: CHEMISTRY OF HETEROCYCLIC COMPOUNDS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.447-456
  • Keywords: benzotriazole, coumarin, 1,2,4-triazol-3-one, antimicrobial activity, catalyst-free reaction, lipase inhibition, microwave irradiation, FLUORESCENT DYES, ANTIMICROBIAL ACTIVITIES, AGENTS, INHIBITORS, ANTIOXIDANT, DESIGN
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

By using the microwave technology, a new protocol has been developed for the synthesis of new coumarin derivatives including 1,2,4-triazol-3-one skeleton. This protocol proves to be efficient and environmentally friendly in terms of easy work-up and good yields. All newly synthesized compounds were screened for their antimicrobial activity and lipase inhibition. Most of the compounds were found to be effective on Escherichia coli. N'-{[4-Amino-3-(2-bromobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetyl}-6-bromo-2-oxo-2Hchromene-3-carbohydrazide and N'-{[4-amino-3-(3,4-dichlorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetyl}-6-bromo-2-oxo-2H-chromene-3-carbohydrazide had a good effect on lipase inhibition.