Serum uric acid level independently predicted metabolic syndrome in non-diabetic hypertensive patients

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YILMAZ A. S., Kahraman F., ERGÜL E., KOÇ H., ÇETİN M.

Arterial Hypertension (Poland), vol.26, no.4, pp.146-152, 2022 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 4
  • Publication Date: 2022
  • Doi Number: 10.5603/ah.a2022.0017
  • Journal Name: Arterial Hypertension (Poland)
  • Journal Indexes: Scopus
  • Page Numbers: pp.146-152
  • Keywords: arterial hypertension, inflammation, insulin resistance, metabolic syndrome, serum uric acid
  • Recep Tayyip Erdoğan University Affiliated: Yes


Background: Arterial hypertension may accompany metabolic syndrome (MetS) which is strongly associated with cardiovascular diseases. Determining high-risk groups concerning MetS development is crucial to prevent this undesirable clinic condition. Serum uric acid level was demonstrated to be associated with development of hypertension and MetS in normal population. This study was aimed to investigate the role of serum uric acid for the prediction of MetS in non-diabetic hypertensive individuals. Material and methods: Patients who were diagnosed with arterial hypertension between January 2021 and June 2021 were included in the study. Diabetes mellitus was determined as an exclusion criterion. Metabolic syndrome was considered as the clustering of high blood pressure, elevated glucose level, abnormal cholesterol levels, and abdominal obesity conditions according to the National Cholesterol Education Program (NCEP) definition. Patients were divided into two groups by the presence of MetS. Results: The mean age of 107 non-diabetic hypertensive patients was 48.5 ± 8.6 years and 50 (46.7%) of them were female. A total of 56 patients (52%) had MetS. Waist circumference (101.2 ± 11.3 vs. 106.7 ± 10.1 cm, p = 0.020), body mass index (30.6 ± 4.9 vs 32.8 ± 4.1, p = 0.016), E/e' ratio [9.2 (7.3-11.1) vs. 10.6 (9.1-13.4), p = 0.003], EAT [5.9 (4.8-8) vs. 7.9 (6-9.6), p = 0.006], and serum uric acid level (4.75 ± 1.10 vs. 5.82 ± 1.21 mg/dL, p < 0.001) were higher in MetS (+) group. Multivariable regression demonstrated that serum uric acid [(odds ratio) OR = 2.217, 95% confidence interval (CI): 1.300-3.783, p = 0.003] and body mass index (OR = 1.214, 95% CI: 1.032-1.428, p = 0.019) were independent predictors of MetS presence. Conclusion: Serum uric acid level independently predicted MetS presence in non-diabetic hypertensive individuals. This practical blood parameter can be used to evaluate those who are at risk of MetS development.