Fibroblast growth factor 21 and its relation to metabolic parameters in women with polycystic ovary syndrome

Sahin S. B. , Ayaz T. , Cure M. C. , SEZGIN H., Ural U. M. , Balik G. , ...More

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, vol.74, no.6, pp.465-469, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 74 Issue: 6
  • Publication Date: 2014
  • Doi Number: 10.3109/00365513.2014.900821
  • Page Numbers: pp.465-469
  • Keywords: Polycystic ovary syndrome, Fibroblast Growth Factor 21, HOMA-IR, dehydroepiandrosterone sulfate, high sensitive C-reactive protein, PPAR-ALPHA, INSULIN SENSITIVITY, FGF21, PREVALENCE, RESISTANCE, ACTIVATION, GLUCOSE, OBESITY, FGF-21


Objective. The aim of this study was to compare the serum levels of fibroblast growth factor 21 (FGF-21) between patients with polycystic ovary syndrome (PCOS) and control subjects and to assess the possible relation with the hormonal and metabolic parameters. Methods. A total of 91 patients with PCOS and 53 age- and body mass index (BMI)-matched healthy controls were included in the study. We evaluated anthropometric, hormonal and metabolic parameters in all the cases. Serum FGF-21 and high sensitive C-reactive protein (hsCRP) levels were measured by ELISA. Results. Mean fasting glucose and insulin, homeostasis model assessment insulin resistance index (HOMA-IR), triglyceride, total cholesterol, low density lipoprotein cholesterol, total testosterone, dehydroepiandrosterone sulfate (DHEAS) levels were significantly higher in PCOS patients. Serum FGF-21 levels were similar in PCOS (236.8 +/- 171.2 pg/ml) and the control (224.6 +/- 128.9 pg/ml) group (p = 0.654). FGF-21 level had no correlation with BMI, waist circumference, HOMA-IR, hsCRP and lipid parameters. However there was a significant negative correlation between FGF-21 and DHEAS levels (r = -0.309, p = 0.003). Conclusion. FGF-21 levels were similar in women with PCOS compared with those of age- and BMI-matched controls.