Gastroesophageal Junction Tumors
Gastrointestinal Tract Tumors: A Current Multimodal Approach and Radiotherapy, NOVA Publications , ss.95-103, 2026
- Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
- Basım Tarihi: 2026
- Yayınevi: NOVA Publications
- Sayfa Sayıları: ss.95-103
- Anahtar Kelimeler: chemotherapy, esophagogastric junction cancers, multimodal approach, predisposing risk factors, radiation therapy, surgery
- Recep Tayyip Erdoğan Üniversitesi Adresli: Evet
Özet
Esophagogastric junction cancers primarily refer to malignancies occurring at the intersection of the esophagus and the stomach, particularly adenocarcinomas. The gastroesophageal junction is a critical anatomical area where the esophagus meets the stomach. Risk factors for developing esophagogastric junction cancers include obesity, smoking, chronic acid reflux, and certain dietary habits. Symptoms often include difficulty swallowing, unexplained weight loss, chest pain, and persistent heartburn. Diagnosis typically involves imaging studies, endoscopy, and biopsy for histological evaluation. Treatment options may include surgery, chemotherapy, radiotherapy, or a combination of these modalities, depending on the stage of the disease and the overall health of the patient. The management of esophagogastric junction cancer involves a multimodal approach that typically combines surgery, chemotherapy, and radiotherapy. Radical surgery is considered the mainstay for the curative treatment of esophagogastric junction cancer and often entails esophagectomy, which is the surgical removal of part or all of the esophagus and potentially the stomach. However, the optimal surgical approach may depend on several factors, including the stage of the cancer, the patient’s overall health, and the anatomical location of the tumor. Preoperative therapies, such as neoadjuvant chemotherapy or chemoradiotherapy, may be employed to shrink the tumor before surgery, helping to improve surgical outcomes and potentially enhance survival rates.