Design, synthesis, and characterization of some new benzimidazole derivatives and biological evaluation

BEKTAŞ H., Sokmen B. B., AYDIN S., Mentese E., Bektas A., Dilekci G.

JOURNAL OF HETEROCYCLIC CHEMISTRY, vol.57, no.5, pp.2234-2242, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 5
  • Publication Date: 2020
  • Doi Number: 10.1002/jhet.3943
  • Journal Name: JOURNAL OF HETEROCYCLIC CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), Chimica, EMBASE
  • Page Numbers: pp.2234-2242
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

A new series of benzimidazole derivatives (1-15) containing 1,2,4-triazole, 1,3,4-thiadiazole, 1,3,4-oxadiazole, and thiazolidinon rings have been synthesized. All new synthesized benzimidazole compounds were confirmed by H-1 NMR, C-13 NMR spectra, and LC-MS, and they were examined for their antioxidant and antimicrobial activities. Compounds 7 and 1 showed the highest and the lowest antioxidant activities, respectively. The lowest minimum inhibition concentration value found in compound 5 against Enterobacter aerogenes.