The olfactory reference syndrome is a psychiatric disorder in which the patients feel they are emitting body odors that might be offensive to other people. They often apologize for the nonexistent odor and engage in activities to rid themselves of the odor. Patients often limit their public appearances and restrict their social and occupational encounters. We present a case of 14 year-old female adolescent who had delusion of emitting a foul body odor, which caused significant symptoms of depression, avoidance behaviors and social isolation. She responded favorably to a combination of 50 mg/d sertraline and 2 mg/d risperidone therapy.