Effects of bone marrow-derived mesenchymal stem cells on doxorubicin-induced liver injury in rats


ÇELİK SAMANCI T., GÖKÇİMEN A., KILIÇ EREN M., Gurses K. M., Pilevneli H., KUYUCU Y.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, vol.36, no.4, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 4
  • Publication Date: 2022
  • Doi Number: 10.1002/jbt.22985
  • Journal Name: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, Applied Science & Technology Source, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, Environment Index, Food Science & Technology Abstracts, MEDLINE
  • Keywords: apoptosis, Doxorubicin, liver toxicity, mesenchymal stem cells, oxidative stress, INDUCED ACUTE HEPATOTOXICITY, INDUCED CARDIAC DYSFUNCTION, ACID, TRANSPLANTATION, CAPACITY, PATHWAY, TISSUE, DAMAGE, MODEL, ASSAY
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

Doxorubicin (DOX) is a potent chemotherapeutic agent and has toxic effects on various organs, including the liver. In the current study, we aimed to investigate the effects of bone-marrow-derived mesenchymal stem cell (BM-MSC) administration on DOX-induced hepatotoxicity in rats. 24 Wistar-albino rats were divided into three groups: Control, DOX, and DOX+MSC. DOX (20 mg/kg) was administered to the DOX group. In the DOX + MSC group, BM-MSCs (2 x 10(6)) were given through the tail vein following DOX administration. DOX administration led to significant structural liver injury. Besides this, oxidative balance in the liver was impaired following DOX administration. DOX administration also led to an increase in apoptotic cell death in the liver. Structural and oxidative changes were significantly alleviated with the administration of BM-MSCs. Furthermore, BM-MSC administration suppressed excessive apoptotic cell death. Our findings revealed that BM-MSC administration may alleviate DOX-induced liver injury via improving the oxidative status and limiting apoptotic cell death in the liver tissue.