Protective effects of hyperbaric oxygen and iloprost on ischemia/reperfusion-induced lung injury in a rabbit model

Bozok S., Ilhan G., YILMAZ Y., DOKUMCU Z., Tumkaya L., KARAMUSTAFA H., ...More

EUROPEAN JOURNAL OF MEDICAL RESEARCH, vol.17, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17
  • Publication Date: 2012
  • Doi Number: 10.1186/2047-783x-17-14
  • Journal Name: EUROPEAN JOURNAL OF MEDICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Hyperbaric oxygen, Iloprost, Ischemia-reperfusion, Lung, Rabbit, INTESTINAL ISCHEMIA-REPERFUSION, LOWER TORSO ISCHEMIA, SKELETAL-MUSCLE, NEUTROPHIL SEQUESTRATION, SPINAL-CORD, TNF-ALPHA, RATS, PERMEABILITY, INHIBITION, ACTIVATION
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

Background: The role of multiorgan damage in the mortality caused by ischemic limb injury is still not clarified. The objective of this study was to examine the potential protective effects of hyperbaric oxygen (HBO) and iloprost (IL) therapy on lung damage induced by limb ischemia/reperfusion injury in a rabbit model, using both biochemical and histopathological aspects.