Inflammatory stress and periodontal tissue destruction in patients with metabolic syndrome and periodontitis

Şenkal R., Yemenoğlu H., Beder M., Köse O., Mataracı Karakaş S., Yılmaz A., ...More

27th Bass Congress, İstanbul, Turkey, 9 - 11 November 2023, pp.95-96

  • Publication Type: Conference Paper / Summary Text
  • City: İstanbul
  • Country: Turkey
  • Page Numbers: pp.95-96
  • Recep Tayyip Erdoğan University Affiliated: Yes


Objective: Metabolic syndrome (MetS) and periodontitis are diseases that lower the quality of life and their incidence rates are increasing. Since both of these diseases are associated with systemic inflammation and insulin resistance, they may be comorbid. The aim of this study was to evaluate the effect of interleukin-20 (IL-20) on periodontal destruction in individuals with MetS. Materials-Methods: A total of 20 individuals with systemically and periodontally healthy, 20 individuals with systemically healthy and periodontitis, 20 individuals with MetS and periodontally healthy, 20 individuals with MetS and periodontitis were enrolled in the present study. Gingival crevicular fluid (GCF) and serum samples were collected from all participants for biochemical analyses. IL-20, receptor activator of nuclear factor kappa B ligand (RANKL) and osteoprotegerin (OPG), total oxidant status (TOS) and total antioxidant status (TAS), matrix metalloproteinase-8 (MMP-8) levels were measured in the GCF and serum samples. For statistical analysis, the Kruskal-Wallis H test, post hoc test with Bonferroni correction, Spearman analysis, and chi-square test were used. Results: GCF and serum IL-20 levels were highest in individuals with Mets and periodontitis (p=0.001). There were a significant positive correlations between GCF and serum IL-20 values and periodontal parameters (p<0.01). RANKL and RANKL/OPG levels increased in the presence of periodontitis (p=0.001) and were positively correlated with IL-20 and clinical parameters (p<0.01). Oxidative stress index values were increased in both periodontitis and MetS (p=0.001) and were positively correlated with GCF IL-20 (p<0.05) and serum IL-20 (p<0.01). Conclusion: IL-20 was found to be associated with both periodontitis and MetS. We suggest that IL-20 may aggravate osseous destruction by both affecting the RANKL/OPG ratio and increasing oxidative stress Keywords: gingival crevicular fluid, interleukin-20, metabolic syndrome, oxidative stress, periodontitis