Akademik Veri Yönetim Sistemi
27th Bass Congress, İstanbul, Türkiye, 9 - 11 Kasım 2023, ss.95-96
Objective: Metabolic syndrome (MetS) and periodontitis are diseases that lower the quality of life and their
incidence rates are increasing. Since both of these diseases are associated with systemic inflammation and insulin
resistance, they may be comorbid. The aim of this study was to evaluate the effect of interleukin-20 (IL-20) on
periodontal destruction in individuals with MetS.
Materials-Methods: A total of 20 individuals with systemically and periodontally healthy, 20 individuals with
systemically healthy and periodontitis, 20 individuals with MetS and periodontally healthy, 20 individuals with MetS
and periodontitis were enrolled in the present study. Gingival crevicular fluid (GCF) and serum samples were
collected from all participants for biochemical analyses. IL-20, receptor activator of nuclear factor kappa B ligand
(RANKL) and osteoprotegerin (OPG), total oxidant status (TOS) and total antioxidant status (TAS), matrix
metalloproteinase-8 (MMP-8) levels were measured in the GCF and serum samples. For statistical analysis, the
Kruskal-Wallis H test, post hoc test with Bonferroni correction, Spearman analysis, and chi-square test were used.
Results: GCF and serum IL-20 levels were highest in individuals with Mets and periodontitis (p=0.001). There were
a significant positive correlations between GCF and serum IL-20 values and periodontal parameters (p<0.01).
RANKL and RANKL/OPG levels increased in the presence of periodontitis (p=0.001) and were positively correlated
with IL-20 and clinical parameters (p<0.01). Oxidative stress index values were increased in both periodontitis and
MetS (p=0.001) and were positively correlated with GCF IL-20 (p<0.05) and serum IL-20 (p<0.01).
Conclusion: IL-20 was found to be associated with both periodontitis and MetS. We suggest that IL-20 may
aggravate osseous destruction by both affecting the RANKL/OPG ratio and increasing oxidative stress
Keywords: gingival crevicular fluid, interleukin-20, metabolic syndrome, oxidative stress, periodontitis