Obesity-Associated Nonalcoholic Fatty Liver Disease

YILMAZ Y., Younossi Z. M.

CLINICS IN LIVER DISEASE, cilt.18, sa.1, ss.19-32, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 1
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.cld.2013.09.018
  • Dergi Adı: CLINICS IN LIVER DISEASE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.19-32
  • Anahtar Kelimeler: Obesity, Nonalcoholic fatty liver disease, Epidemiology, Pathophysiology, LIFE-STYLE MODIFICATION, BODY-MASS INDEX, UNITED-STATES, METABOLIC SYNDROME, BARIATRIC SURGERY, PHYSICAL-ACTIVITY, BIOMARKER PANEL, ADIPOSE-TISSUE, RISK-FACTORS, STEATOHEPATITIS
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Hayır

Özet

Obesity is strongly associated with the prevalence of nonalcoholic fatty liver disease (NAFLD) in adult and pediatric populations. Nutrition, physical activity, and behavioral modifications are critical components of the treatment regimen for all obese patients with NAFLD. Bariatric surgeries that affect or restrict the flow of food through the gastrointestinal tract may improve liver histology in morbidly obese patients with nonalcoholic steatohepatitis (NASH), although randomized clinical trials and quasi-randomized clinical studies are lacking. Early detection of NASH and hepatic fibrosis using noninvasive biochemical and imaging markers that may replace liver biopsy is the current challenge.